Open AccessA Cytokinetic Study of Small‐Intestinal and Colonic Mucosa After Resection of 70% of the Small Intestine
Author(s) -
Senior P. V.,
Pritchett C. J.,
Sunter J. P.,
Appleton D. R.,
Watson A. J.
Publication year - 1986
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1986.tb00748.x
Subject(s) - crypt , ileum , small intestine , jejunum , biology , thymidine , intestinal mucosa , mitosis , pathology , medicine , microbiology and biotechnology , endocrinology , in vitro , biochemistry
. Pulse‐labelling with tritiated thymidine and a fraction of labelled mitoses experiments have been performed in order to investigate the proliferative changes induced at various sites in the hyperplastic small‐intestinal mucosa of rats previously subjected to resection of 70% of the small intestine. Proliferative activity in the colon was also studied. In the distal ileum there is a significant reduction in cell cycle time (T c ) of cells at all levels within the crypt and the growth fraction falls. In the jejunum and proximal ileum the crypts contain an increased number of proliferating cells, but as the size of the maturation zone is also increased, there is no significant alteration in the relative number of proliferating cells per crypt. Nor does the distribution of proliferating cells in these crypts seem to alter. There is no general reduction in T c at these sites, but there does appear to be a significant reduction in T c on the part of the cells in the stem‐cell zone at the crypt base. In neither proximal nor distal colon was there any significant proliferative change apparent after small‐intestinal resection.