Open AccessChromatographic Analysis of Gastrin‐Releasing Peptide In Heat‐Inactivated Fetal Calf Serum
Author(s) -
Wiedermann C. J.,
Goldman M. E.,
Pert C. B.
Publication year - 1986
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1986.tb00744.x
Subject(s) - gastrin , peptide , gastrin releasing peptide , chemistry , fetus , peptide hormone , endocrinology , medicine , biochemistry , biology , neuropeptide , receptor , secretion , bombesin , pregnancy , genetics
. Gastrin‐releasing peptide and the carboxyterminal fragments gastrin‐releasing peptide [14‐27] and [18‐27] are found by radioimmunology and high performance liquid chromatography to be present in heat‐inactivated fetal calf sera. Peptides containing the carboxyterminal sequence of gastrin‐releasing peptide are known to display mitogenic activity. Thus, gastrin‐releasing peptide represents a new class of mitogenic factors that are present in heat‐inactivated fetal calf serum.