Open AccessCell Growth and Cell Division: Dissociated and Random Initiated?
Author(s) -
Sennerstam R.,
Stromberg J. O.
Publication year - 1986
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1986.tb00716.x
Subject(s) - cell cycle , cell division , cytoplasm , transition (genetics) , nucleus , biology , cell growth , cell , microbiology and biotechnology , division (mathematics) , period (music) , restriction point , dna synthesis , genetics , dna , gene , mathematics , cell cycle progression , physics , arithmetic , acoustics
. The ‘random transition probability’ cekycle models have so far failed to convincingly link the transition events with phenomena describable by biochemical methods. the study presented was carried out on the F9 and PCC3 N/1 embryonal carcinoma (EC) cell lines. We now report an extended analysis of the two‐random transition probability (TP) model and preliminary results are presented showing that the deterministic L period in that model can be regarded as reflecting the ‘cell‐growth cycle’. Evidence is presented that suggests that the ‘cell‐growth cycle’ is a supramitotic deterministic phase—i.e. starting in one cell cycle and being completed in the next following G 1 period and dissociated from the ‘DNA‐division cycle’. This phenomenon makes an interesting contribution to the old knowledge of a stepwise G 1 prolongation during early embryogenesis in yielding a mechanism by which the cell can alter the ratio of nucleus to cytoplasm prior to the onset of gene expression.