Open AccessGrowth Rate Regulation and Random Transition A study performed on embryonal carcinoma cell lines. I.
Author(s) -
Sennerstam R.,
Strömberg J. O.
Publication year - 1986
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1986.tb00715.x
Subject(s) - embryonal carcinoma , cell cycle , cell culture , biology , microbiology and biotechnology , cell growth , cell , transition (genetics) , embryonic stem cell , embryo , cellular differentiation , genetics , gene
. Analyses of cell‐cycle characteristics of the three embryonal carcinoma (EC) cell lines F9, PCC3 N/1 and PCC4 Azal, have been performed. the three lines reflect successive stages in early mouse embryogenesis as regards cell surface antigens and cell‐cycle characteristics. In an attempt to understand changes in cell‐cycle characteristics occurring during early embryogenesis, the two‐random transition probability (TP) model was applied to the EC‐cell system—and particularly to the F9 line. By utilizing an intraclonal heterogeneity in intermitotic times found in these EC lines, a growth‐regulating point was introduced as a modification of the two‐random TP model. the modified model was found to be very useful when demonstrating the cell‐cycle growth kinetics of the F9 line. the model is used in an accompanying paper to extend the analysis of cell‐cycle characteristics in undifferentiated EC cells.