Open AccessPig Epidermis: A Cell Kinetic Study
Author(s) -
Morris G. M.,
Hopewell J. W.
Publication year - 1985
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1985.tb00671.x
Subject(s) - epidermis (zoology) , microbiology and biotechnology , biology , cell , chemistry , anatomy , biochemistry
The basal cell density (BCD), labelling index (LI), duration of DNA synthesis (T s ) and cell cycle time (T c ) have been calculated for the epidermis of pigs in the age range 4–27 months. the BCD declined progressively from 143.4 ± 6.5 cells/mm at 4 months to 128.8 ± 8.3 cells/mm at 15 months, whereafter the values showed little change. There was a small decrease in LI with increasing age, from 7.9 ± 1.5% at 4 months to 5.9 ± 1.0% at 27 months. However, the change to housing animals outdoors as compared with indoors had a greater effect on the LI (∼10%). Severe weathering in the skin of animals housed outdoors resulted in a very high LI (∼20%). Neither T s or T c varied significantly with age. T s was within the range 8.8–9.2 hr and T c 127–161 hr. In animals housed outdoors T c was reduced relative to animals housed indoors. the BCD and T s were not affected by housing conditions. the kinetic parameters investigated in the pig were similar to those reported for man.