Open AccessVindesine As A Stathmokinetic Agent In Human Rectal Tumours In Organ Culture
Author(s) -
Pritchett C. J.,
Senior P. V.,
Sunter J. P.,
Watson A. J.,
Appleton D. R.,
Wilson R. G.
Publication year - 1985
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1985.tb00657.x
Subject(s) - vindesine , biology , medicine , chemotherapy , vincristine , cyclophosphamide
Organ culture, using human colorectal mucosa and tumours, is a good system in which to test a new stathmokinetic agent such as vindesine. Using this system we have found that vindesine has similar metaphase‐arresting properties to vincristine, including at least a 6‐fold dose response difference in its ability to arrest mitosis in mucosa and tumour, mucosa being the more sensitive. Vindesine is a satisfactory stathmokinetic agent, but in view of its greater cost offers no particular advantages over vincristine.