Open AccessEffect of Haemopoietic Stem‐Cell Proliferation Regulators On Early and Late Spleen Colony‐Forming Cells
Author(s) -
Wright E. G.,
Lorimore S. A.,
Lord B. I.
Publication year - 1985
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1985.tb00648.x
Subject(s) - spleen , bone marrow , biology , stem cell , haematopoiesis , cfu gm , colony forming unit , immunology , cell growth , transplantation , microbiology and biotechnology , andrology , medicine , biochemistry , genetics , bacteria
An inhibitor and stimulator of CFU‐s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU‐s (e.g. normal bone marrow) and proliferating CFU‐s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady‐state and regenerating marrow CFU‐s, which produce colonies 7, 10 and 12 days post‐transplantation have been investigated. The results demonstrate changing sensitivities of CFU‐s to inhibitor and stimulator as they progress through a developmental age structure. ‘Older’ CFU‐s (producing early spleen colonies) are more sensitive to stimulator, ‘Younger’ CFU‐s (producing late spleen colonies) are more sensitive to inhibitor.