Open AccessSome Mechanisms of Disturbances and Recovery of T‐Lymphocyte Migratory Properties In Irradiated Mice
Author(s) -
Anokhin George N.,
Yarilin Alexander A.
Publication year - 1984
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1984.tb00568.x
Subject(s) - irradiation , trypsin , lymph node , cell migration , in vitro , cell , t lymphocyte , immunology , chemistry , biology , microbiology and biotechnology , andrology , medicine , enzyme , biochemistry , physics , nuclear physics
Migration of 51 Cr‐labelled T cells from irradiated mice into lymph nodes of syngeneic unirradiated recipients decreased in a dose‐dependent fashion. Influx of labelled T cells between 4 and 24 hr after injection (secondary migration) is more radiosensitive than lymph‐node migration of T cells in the first 4 hr (primary migration). Treatment of T cells from irradiated mice in vitro with Con A or with trypsin does not enhance radiation‐induced alteration of their migratory properties, but irradiation enhances the effects of Con A and trypsin on T‐cell migration. Recovery of primary migration of irradiated T cells is completed 3 months after irradiation; it is probably caused by T‐cell renewal. the defect of T‐cell secondary migration is more stable: it remains 6 months after irradiation in a dose of 4 Gy. Post‐irradiation defects of the T‐cell differentiation process as a cause of long‐lasting alteration of T‐cell secondary migration are discussed.