Open AccessEffect of low‐dose whole‐body irradiation on granulopoietic progenitor cell subpopulations: implications for CFUc release
Author(s) -
Gerhartz H. H.,
Nothdurft W.,
Fliedner T. M.
Publication year - 1982
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1982.tb01054.x
Subject(s) - progenitor cell , bone marrow , thymidine , biology , immunology , irradiation , stem cell , microbiology and biotechnology , cancer research , dna , biochemistry , physics , nuclear physics
. The reaction of the granulopoietic system to whole body irradiation with 0.80 and 1.60 Gy was studied in dogs by means of colony formation assays in combination with velocity sedimentation and tritiated thymidine cytocidal techniques. Depression of circulating CFUc was associated with a marked shift in the size distribution of granulopoietic progenitors in the bone marrow. This effect lasted much longer in those animals receiving the lower X‐ray dose. We conclude that circulating CFUc are not a random proportion of the bone marrow but a subpopulation of cells which are smaller in size. These cells are in an equilibrium with the larger marrow CFUc, which is very sensitive to perturbations.