Open AccessCell kinetics of lithium‐induced granulopoiesis
Author(s) -
Gallicchio V. S.,
Chen M. G.
Publication year - 1982
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1982.tb01036.x
Subject(s) - granulopoiesis , lithium (medication) , erythropoiesis , dna synthesis , thymidine , inducer , chemistry , kinetics , mechanism of action , medicine , endocrinology , progenitor cell , biophysics , microbiology and biotechnology , biochemistry , biology , dna , stem cell , in vitro , anemia , physics , quantum mechanics , gene
. Lithium has been shown to be an effective inducer of granulopoiesis. The mechanism of lithium action has been shown to influence CFU‐s and CFU‐c proliferation, increase colony‐stimulating factor (CSF) production and reduce erythropoiesis. We report here evidence to show that lithium recruits CFU‐c that are not normally in the cell cycle into active DNA synthesis, as measured by hydroxyurea and tritiated thymidine suicide techniques. Furthermore, lithium action is shown to be time‐dependent, since the delay addition of lithium for 5 min to normal bone marrow removes the enhancement usually seen when lithium is given at time zero. The implications of these lithium‐induced effects are described.