Open AccessLOCAL MITOGENIC EFFECT OF TISSUE MAST CELL SECRETION
Author(s) -
Franzén L.,
Norrby K.
Publication year - 1980
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1980.tb00502.x
Subject(s) - degranulation , mast cell , histamine , fibroblast , compound 48/80 , secretion , biology , microbiology and biotechnology , mesentery , cell culture , immunology , endocrinology , anatomy , biochemistry , receptor , genetics
The effect of drug‐induced mast cell secretion on proliferation was studied in fibroblast‐like and mesothelial‐like cells in organ‐cultured rat mesentery. Mast cell degranulation achieved by Compound 48/80 was followed by a marked mitogenic reaction in the surrounding tissue cells. The drug itself lacked mitogenic effect on cultured guinea‐pig mesentery, the mast cells of which are unresponsive to the drug, and on a human normal fibroblast‐like cell line. In contrast, histamine at about 10 −10 M, a major mast cell component, induced marked mitogenesis in guinea‐pig mesentery without causing degranulation of mast cells. It is concluded that secreting rat‐tissue mast cells release a mitogenic factor or factors acting locally on nearby tissue cells.