Open AccessLACK of DNA SYNTHESIS INHIBITORY ACTIVITY IN an IMMUNOSUPPRESSOR OBTAINED FROM SPLEEN
Author(s) -
DIATLOFF C.,
BENGTSON A.,
BILLARDON C.,
OELHO A. MACIEIRAC
Publication year - 1978
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1978.tb00898.x
Subject(s) - spleen , in vivo , purine , dna , dna synthesis , inhibitory postsynaptic potential , chemistry , in vitro , pyrimidine , biochemistry , microbiology and biotechnology , biology , enzyme , immunology , neuroscience
A tissue extract derived from bovine spleen which is an immunosuppressor in vivo inhibits the incorporation of the two DNA pyrimidine nucleosides but does not inhibit the incorporation of purine nucleosides. the results indicate that the immunosuppressive action of the spleen extract is not mediated via inhibition of cell division.