Open AccessCell Kinetics In the Erythroid Compartment of Guinea Pig Bone Marrow: A Model Based On 3 H‐Tdr Studies
Author(s) -
Prothero J.,
Starling M.,
Rosse C.
Publication year - 1978
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1978.tb00897.x
Subject(s) - compartment (ship) , guinea pig , erythropoiesis , basophilic , kinetics , bone marrow , biophysics , flux (metallurgy) , biology , microbiology and biotechnology , biological system , chemistry , immunology , physics , pathology , genetics , medicine , geology , oceanography , organic chemistry , quantum mechanics , anemia
A model of steady‐state erythropoiesis in the guinea pig is described. the model incorporates an unidentified progenitor compartment, as well as compartments representing proerythroblasts, basophilic, polychromatic and orthochromatic cells. A computer representation of the model permits a simulation of the labeling curves obtained in pulse and intermittent labeling regimes. It was found that a reasonable fit to the data can be achieved when the parameters for the various compartments are essentially identical. the results of a preliminary sensitivity analysis, carried out by perturbing the duration of S phase from the best fit value, are reported. the fit achieved to the data supports the hypothesis underlying the model that each compartment corresponds to one generation and that the flux within and between compartments is sequential.