Open AccessABILITY OF THYMIC LYMPHOCYTES TO ALTER CFU KINETICS IN RADIATION CHIMERAS
Author(s) -
Shinpock Sarah Garner,
Goodman Joan Wright
Publication year - 1978
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1978.tb00879.x
Subject(s) - haematopoiesis , spleen , bone marrow , biology , cell division , exponential growth , immunology , thymidine , microbiology and biotechnology , cell , andrology , stem cell , medicine , biochemistry , dna , mathematical analysis , mathematics
It is known that the poor colony‐forming ability of B6 bone marrow transplanted into B6D2F 1 hybrids can be improved if B6 lymphocytes are given in addition. It was recently reported that the augmenting lymphocytes decrease the doubling time of differentiating hemopoietic cells. to determine whether thymus cells alter the self‐renewal of CFUs in this parent F 1 combination, retransplan‐tation and 3 H‐thymidine ‘suicide’ were employed as methods to determine the cell‐division rate. We have observed that in the presence of thymocytes, parental bone marrow cells are seeded more efficiently in the spleen, and the lag phase of the CFUs growth curve is shortened. However, thymic lymphocytes do not increase the slope of the exponential growth phase of CFUs.