Open AccessDEVELOPMENT OF HAEMATOPOIETIC COLONIES ON THE MACROPHAGE LAYER FORMED IN THE PERITONEAL CAVITY OF S1/S1 D MICE
Author(s) -
Miyano Y.,
Tamai M.,
Kitamura Y.
Publication year - 1978
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1978.tb00878.x
Subject(s) - peritoneal cavity , macrophage , haematopoiesis , spleen , biology , bone marrow , immunology , microbiology and biotechnology , stem cell , anatomy , genetics , in vitro
The colony‐forming ability of haematopoietic cells was examined on the macrophage layer formed in the peritoneal cavity of S1/S1 d mice. the bone marrow cells of the congenic +/+ mice formed many macroscopic colonies on the macrophage layer of the S1/S1 d mice although they did not form macroscopic colonies in the spleens of the same S1/S1 d recipients. the size and the differentiation pattern of colonies on the macrophage layer of the S1/S1 d mice were comparable to those of the colonies on the macrophage layer of the +/+ mice. There are two possible explanations for these results: (a) the microenvironmental defect of the S1/S1 d mice has a more prominent effect on the development of spleen colonies than that of macrophage‐layer colonies because ‘Steel’ locus may not be expressed significantly in the peritoneal macrophages or (b) because the cells that make colonies on the macrophage layer may be more differentiated cells than the multipotential stem cells that make colonies in the spleen.