Open AccessDissecting the Hematopoietic Microenvironment
Author(s) -
Wolf N. S.
Publication year - 1978
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1978.tb00805.x
Subject(s) - erythropoiesis , haematopoiesis , bone marrow , spleen , anemia , ineffective erythropoiesis , peripheral blood , biology , immunology , microbiology and biotechnology , medicine , physiology , endocrinology , stem cell
An analysis of the S1/S1 d mouse for ferrokinetics and fate of peripheral red blood cells has shown the cause of its anemia to be dual in nature. While the S1/S1 d produces red cells at a slightly greater rate than its normal littermate, its bone marrow and spleen appear to be operating near their maximal capacity and will reduce their output if anemic stress is partly relieved. the cause of the moderately high level of erythropoiesis in the S1/S1 d is a mean daily loss of 2.5–3.0% of its total blood volume via the intestinal tract.