Open AccessAN IN VIVO STATHMOKINETIC STUDY OF CELL PROLIFERATION IN HUMAN GASTRIC CARCINOMA AND GASTRIC MUCOSA
Author(s) -
Wright Nicholas A,
Britton David C.,
Bone George,
Appleton David R.
Publication year - 1977
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1977.tb00861.x
Subject(s) - in vivo , vincristine , gastric mucosa , carcinoma , stomach , biology , in vitro , cell , pathology , stage (stratigraphy) , gastric carcinoma , human stomach , medicine , cancer , chemotherapy , cyclophosphamide , biochemistry , paleontology , microbiology and biotechnology
Cell production rates were studied in a group of eleven patients with carcinoma of the stomach using an in vivo technique with vincristine. In normal pyloric mucosa estimates ranged from 8 to 15 cells/1000 cells/hr, and in the carcinomas from 3 to 24 cells/1000 cells/hr. Because of the very large variation in the data, comparison between individual tumours and normal mucosa is not regarded as being worth while at this stage. The implications of these results for previous human in vivo stathmokinetic experiments are also discussed.