Open AccessAN EXTENDED TRANSITION PROBABILITY MODEL OF THE VARIABILITY OF CELL GENERATION TIMES
Author(s) -
Svetina S.
Publication year - 1977
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1977.tb00314.x
Subject(s) - constant (computer programming) , population , kinetics , probability model , generation time , probability distribution , phase transition , population model , steady state (chemistry) , statistics , mathematics , thermodynamics , chemistry , physics , computer science , demography , quantum mechanics , sociology , programming language
The transition probability model of variability of cell generation times is extended so that the rate constant for the transition from the A‐state to the B‐phase of the cell cycle depends on time which a particular cell has already spent in the A‐state. A specific time dependence of this rate constant is introduced. It is determined by the value of one constant which is then an additional parameter of the model. The corresponding cell population kinetics are calculated and compared to existing experimental evidence. The model accounts satisfactorily for the generation time distribution function and for the shortening of the G 1 phase of binucleate cells. The time dependence of the transition probability is related to the cell kinetics of an hypothetical cell constituent. A possible relationship is proposed between the chemical parameters within the cell and the parameters of the cell population kinetics.