Open AccessTHE EFFECT OF E TYPE PROSTAGLANDINS ON THE PROLIFERATION OF HAEMOPOIETIC STEM CELLS IN VIVO
Author(s) -
Gidȧli J.,
Fehėr I.
Publication year - 1977
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1977.tb00304.x
Subject(s) - haematopoiesis , in vivo , stem cell , stimulation , biology , in vitro , microbiology and biotechnology , cfu gm , chemistry , andrology , endocrinology , immunology , biochemistry , medicine
The ability of protaglandins E 1 and E 2 to stimulate the proliferation of haemopoietic stem cells (CFU s ) was studied in vivo. PGE 2 , in a dose range of 10 ‐4 to 10 ‐1 μg/g body weight and PGE 1 in a dose range of 10 ‐5 to 10 ‐1 μg/g body weight, produced a rapid cycling wave of CFU s . The increase in the number of CFU s in S phase was not followed by a rise in the femoral CFU s content, and except for a transient increase in femoral CFU c level, no increase in differentiation was found either. Therefore, it is proposed that haemopoiesis after PG‐induced CFU stimulation is ineffective. PGE 2 did not stimulate regeneration of CFU s in a perturbed state (after sublethal irradiation). All these findings support the idea that PGEs might represent potent stimulators of the haemopoietic stem cells acting in physiological doses. However, if acting concurrently with physiological control systems PGs lead to ineffective haemopoiesis (under normal conditions) or do not exert any measurable effect (after sublethal irradiation).