Open AccessEFFECTS OF PRE‐IRRADIATION ON ISOGENEIC AND SEMI‐ISOGENEIC CFU GROWTH: A STUDY ON GENETIC RESISTANCE
Author(s) -
Buurman W. A.,
Bruggen Ivonne van
Publication year - 1977
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1977.tb00279.x
Subject(s) - spleen , bone marrow , irradiation , biology , transplantation , bone marrow transplantation , andrology , immunology , medicine , physics , nuclear physics
The genetic resistance to a parental bone marrow transplant as demonstrated, when transplantation was performed early after irradiation, failed to occur if the interval between irradiation and transplantation was increased to 4 days. A similar radiation induced weakening of genetic resistance to a parental bone marrow graft in spleen and bone marrow could be demonstrated in mice, which had been irradiated with a sublethal dose at 7 days prior to the lethal irradiation and transplantation. The pre‐irradiation of the recipient with a sublethal dose induced an enhancement of the growth in spleen and bone marrow of isogeneic transplanted CFU. The pre‐irradiation of a single tibia also resulted in a significant weakening of the resistance in the spleen. The experiments with partial body pre‐irradiation suggested a local effect of the pre‐irradiation, but it could be shown that the enhanced CFU growth is not caused by an enhanced seeding of CFU in pre‐irradiated bone marrow. The role of microenvironment in the phenomenon of genetic resistance is discussed.