Open AccessTHE KINETICS OF CONTACT INHIBITION IN MAMMALIAN CELLS
Author(s) -
Schmialek P.,
Geyer Astrid,
Miosga Verena,
Nündel M.,
Zapf B.
Publication year - 1977
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1977.tb00144.x
Subject(s) - kinetics , chemistry , microbiology and biotechnology , biophysics , biology , physics , quantum mechanics
To elucidate the process of contact inhibition in mammalian cells, we investigated the kinetics of growth arrest in [ 3 H]thymidine labelled embryonic chinese hamster ( Cricetulus griseus L.) cells after the addition of various concentrations of unlabelled cells. It was observed that after the contact inhibition concentration had been reached, the cells grew undisturbed for one more generation. In the following 24 hr the concentration fell back to the level at the beginning of the experiment and stayed there.