Open AccessEFFECT OF MECHANICAL STIMULATION ON CELL PROLIFERATION IN MOUSE EPIDERMIS AND ON GROWTH REGULATION BY ENDOGENOUS FACTORS (CHALONES)
Author(s) -
Bertsch Stefan,
Csontos Katharina,
Schweizer Jurgen,
Marks Friedrich
Publication year - 1976
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1976.tb01295.x
Subject(s) - epidermis (zoology) , stimulation , hyperplasia , microbiology and biotechnology , mitosis , endogeny , population , regeneration (biology) , cell , cell growth , chemistry , cell division , biology , endocrinology , medicine , anatomy , biochemistry , environmental health
Mechanical stimulation of dorsal mouse skin by skin massage or removal of the horny layer results in a mutually comparable increase in DNA‐labelling and mitotic activity. However, only after injury such as removal of the horny layer hyperplasia develops. This phenomenon, called ‘hyperplastic transformation’ is characterized by a transient abolition of the epidermal G 1 chalone responsiveness. There is some indication that the susceptibility to a heat labile factor, probably the epidermal G 2 chalone, is not affected. Skin massage neither interferes with the responsiveness to epidermal G 1 chalone nor induces ‘hyperplastic transformation’. Mouse tail epidermis shows a ‘functional hyperplasia’ and responds to the G 1 chalone. To explain these observations, it is assumed that the epidermal stem cell population is heterogeneous consisting of G 1 chalone‐sensitive and G 1 chalone‐insensitive cells.