Open AccessTHE ROLE OF THE SPLEEN IN THE REPOPULATION OF THE HAEMOPOIETIC SYSTEM OF HEAVILY‐IRRADIATED MICE
Author(s) -
Silini G.,
Andreozzi U.,
Pozzi L. V.
Publication year - 1976
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1976.tb01282.x
Subject(s) - spleen , bone marrow , repopulation , progenitor cell , biology , haematopoiesis , regeneration (biology) , stem cell , immunology , progenitor , microbiology and biotechnology
The respective role of the spleen or of the bone marrow in the regeneration of the haemopoietic progenitor compartment of heavily‐irradiated mice has been investigated. Splenectomy was used to this end in animals injected with exogenous isogenic cells or regenerating from endogenous spleen or marrow cells. Analysis of the data as a function of time shows that the presence of the spleen affects marrow CFU repopulation only at the early post‐irradiation stages. The expansion of the marrow progenitor pool proceeds, however, rather independently of the spleen and marrow CFU remain eventually as the main source of haemopoietic cells in the surviving mice. Thus the reaction of the spleen may be envisaged as a fast, important but transient contribution to the overall haemopoietic function of heavily‐irradiated animals.