Open AccessPERIODONTAL LIGAMENT CELL KINETICS FOLLOWING ORTHODONTIC TOOTH MOVEMENT
Author(s) -
Yee J. A.,
Kimmel D. B.,
Jee W. S. S.
Publication year - 1976
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1976.tb01276.x
Subject(s) - periodontal fiber , fibroblast , stimulation , progenitor cell , osteoblast , chemistry , population , thymidine , dna synthesis , cell , kinetics , microbiology and biotechnology , cell division , dna , anatomy , dentistry , endocrinology , biology , stem cell , in vitro , medicine , biochemistry , physics , environmental health , quantum mechanics
The population of periodontal ligament (PDL) fibroblasts examined in this study may include osteogenic progenitor cells. PDL fibroblast and osteoblast kinetics in the periodontal ligament of the rat were measured following orthodontic stimulation of bone formation. Both single and multiple injections of tritiated thymidine ( 3 H‐TdR) were used. In single injection experiments, the peak percentage of PDL fibroblasts labeled with 3 H‐TdR is 15% at 22 hr post‐stimulation. In multiple injection experiments, the total percentage of fibroblasts in the PDL which respond by synthesizing DNA is 50%. 3 H‐TdR‐Iabeled osteoblasts appear at the same rate as, but with a time delay after, the labeled fibroblasts. Following stimulation, the most likely source of osteoblasts at the bone‐forming site is not only fibroblasts which make DNA, divide, then differentiate, but also fibroblasts which either are differentiated to osteoblasts without DNA synthesis and cell division, or are released from G 2 block by the orthodontic stimulation.