Open AccessTHE CELL PROLIFERATION KINETICS OF THE EMT6/M/AC MOUSE TUMOUR AT FOUR VOLUMES DURING UNPERTURBED GROWTH IN VIVO
Author(s) -
Watson James V.
Publication year - 1976
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1976.tb01262.x
Subject(s) - in vivo , fibrosarcoma , cell growth , kinetics , cell , cell cycle , biology , chemistry , microbiology and biotechnology , biochemistry , genetics , physics , quantum mechanics
The cell proliferation kinetics of the EMT6/M/AC mouse tumour were determined at four different volumes between 1–5 mm 3 and 175 mm 3 . The decrease in the growth rate between these volumes was mainly due to a decrease in the rate constant for cell production. A small increase in the rate constant for cell loss occurred, but this was thought to be insignificant. The cell loss factor increased from 40% at 1–5 mm 3 to over 70% in the 175 mm 3 tumours. An increase in the median cell cycle time, from 14‐1 hr to 18‐5 hr was also found between these same volumes. Results obtained for the NCTC fibrosarcoma and the R‐l rhabdomyosarcoma indicate that there may be a threshold volume in these sarcomas below which little or no cell loss takes place. This was not found in the EMT6/ M/AC tumour.