Open AccessAGE DEPENDENCE OF THE NUMBER OF THE STEM CELLS IN HAEMOPOIETIC TISSUES OF RATS
Author(s) -
VACEK ANTONÍN,
BARTONÍĈKOVÁ ALENA,
TKADLEĈEK LUDVÍK
Publication year - 1976
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1976.tb01248.x
Subject(s) - spleen , stem cell , bone marrow , biology , senescence , haematopoiesis , andrology , immunology , colony forming unit , microbiology and biotechnology , medicine , genetics , bacteria
The number and concentration of haemopoietic stem cells in the femoral bone marrow and spleen of Wistar rats of different ages were investigated. Stem cells were assayed by the spleen colony technique in irradiated rat recipients. The ability of the recipient spleen to harvest transplanted tissue as a macroscopic colony was found to be dependent on the recipient's age. Changes with senescence were observed also in the concentration and the size of the stem cell compartment both in the marrow and spleen. No differences were demonstrated in the seeding of transplanted colony‐forming units into the spleen of recipients of 1 and 4 months of age. A rats‐mice strain difference in the effect of senescence on the haemopoietic stem cells is discussed.