Open AccessMETALLIC COPPER‐INDUCED GRANULOCYTE EXUDATION IN THE STUDY OF GRANULOCYTOPOIESIS
Author(s) -
McGarry Michael P.
Publication year - 1975
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1975.tb01499.x
Subject(s) - myelopoiesis , granulocyte , peritoneal cavity , stimulation , bone marrow , peripheral blood mononuclear cell , granulopoiesis , haematopoiesis , in vitro , immunology , monocyte , chemistry , biology , endocrinology , microbiology and biotechnology , anatomy , biochemistry , stem cell
C3H/HeHa mice implanted with rods of metallic copper (CR) or glass (GR) exudate neutrophil granulocytes and mononuclear cells into the site of rod implant (peritoneal cavity). Exudation in CR mice is substantially greater than in GR animals. In CR mice there is an impressive stimulation of myelopoiesis measured in the femoral marrow subsequent to the initial accumulation in the peritoneal cavity. Serum levels of colony stimulating activity (CSA), an in vitro myeloproliferative stimulating activity, are elevated in such animals, as are femoral marrow agar‐colony forming cells (CFC). The procedure is useful to the study of myelopoiesis and myelopoietic regulatory mechanisms.