Open AccessMATRIX SIMULATION OF DUODENAL CRYPT CELL KINETICS
Author(s) -
Roti Joseph L. Roti,
Dethlefsen Lyle A.
Publication year - 1975
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1975.tb01497.x
Subject(s) - crypt , cell division , mitosis , matrix (chemical analysis) , population , steady state (chemistry) , thymidine , kinetics , function (biology) , microbiology and biotechnology , cell , biology , chemistry , physics , biochemistry , in vitro , endocrinology , medicine , environmental health , chromatography , quantum mechanics
Steady state crypt cell kinetics have been simulated using matrix algebra. The model crypt cell population is distributed through two proliferation compartments (P 1 and P 2 ) and a quiescent state (Q). Under steady state conditions half the daughter cells produced on completion of P 1 enter G 1 of P 2 and half enter G 1 of P 1 . Both P 2 daughter cells enter Q. Cells in Q are non‐dividing but retain the potential to divide. On completion of Q, cells lose the potential to divide and move up onto the villi. The model has been developed by simultaneously simulating the following biological data: (1) the per cent labeled mitosis (PML) curve, (2) the number of labeled cells per crypt as a function of time following an injection of 3 H‐thymidine, and (3) the total number of cells per crypt.