Open AccessTHE PRESENCE OF A CSF ENHANCING ACTIVITY IN THE SERUM OF ENDOTOXIN‐TREATED MICE
Author(s) -
Engh Ger van den,
Bol Simon
Publication year - 1975
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1975.tb01244.x
Subject(s) - myelopoiesis , colony stimulating factor , in vitro , serum concentration , biological activity , pharmacology , biology , immunology , chemistry , endocrinology , medicine , haematopoiesis , biochemistry , microbiology and biotechnology , stem cell
Serum taken from mice a few hours after injection of endotoxin is a potent source of a stimulator of in vitro myelopoiesis. By means of dose‐response studies, the biological activity of this material was compared to that of a colony stimulating factor (CSF) from pregnant mouse uteri. Postendotoxin serum appears to contain two different activities: a stimulating activity which may be identical to CSF and an activity which augments the action of CSF. The separate nature of the two activities is demonstrated by differences in the rate at which they are diluted out and by differences in the time at which they are maximally present after endotoxin administration. It is therefore concluded that the colony‐stimulating properties of postendotoxin serum are not due solely to CSF present in the serum.