Open AccessTHE EFFECT OF ESTRADIOL ON THE CELL KINETICS IN THE UTERINE AND CERVICAL EPITHELIUM OF NEONATAL MICE
Author(s) -
Eide Arne
Publication year - 1975
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1975.tb01223.x
Subject(s) - uterus , epithelium , medicine , endocrinology , hormone , andrology , estrogen , biology , chemistry , genetics
The effect of estradiol‐17β on the length of the various phases of the cell cycle was studied in the neonatal mouse uterine, and cervical epithelium. A double labelling method was used, and in addition labelled mitoses were counted. In the uterus proper, estradiol shortens the length of the total cell cycle, T c , from 17‐9 hr to 15‐7 hr, and the duration of S phase, T s, from 6–7 to 5‐1 hr 6 hr after estradiol treatment. 12 hr after estradiol treatment, T c is shortened to 7‐4 hr and T s to 4–5 hr. The shortening of T c at 12 hr is mainly due to an effect on T G1 , which is shortened from 8–55 hr in untreated animals to 1–8 hr in estradiol treated animals. The T c of cervix epithelium cells in untreated animals was found to be 21‐8 hr. After treating the mice for 6 hr with estradiol the T c was now increased to 47 hr and further to 61 ‐2 hr following 12 hr treatment with the hormone. T s increases from 8‐3 hr to 15‐2 hr following 6 hr estradiol treatment, and to 15‐4 hr after 12 hr treatment. The effect is most pronounced in T G1 , which is lengthened from 10–95 hr in untreated animals to 28‐1 hr and 43 hr, respectively, in animals treated for either 6 or 12 hr with estradiol.