Open AccessVARIATIONS OF MITOSIS‐INHIBITING CHALONE ACTIVITY IN EPIDERMIS AND DERMIS AFTER CARCINOGEN TREATMENT
Author(s) -
Rohrbach R.,
Laerum O. D.
Publication year - 1974
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1974.tb00905.x
Subject(s) - dermis , epidermis (zoology) , mitosis , carcinogen , hyperplasia , microbiology and biotechnology , regeneration (biology) , cell growth , cell , dna synthesis , biology , chemistry , biochemistry , anatomy , dna , endocrinology
During regeneration and hyperplasia following a single application of a carcinogen to mouse epidermis, the rate of epidermal cell proliferation varied inversely with the content of mitosis‐inhibiting activity (chalone). The main inhibitory activity was present within the epidermal cells, but a lesser activity was also found in the corresponding extracts of dermis. This supports the concept that chalones act as physiological regulators of cellular proliferation under pathological as well as normal conditions. The possibility that the dermis also takes an active part in this regulation is discussed.