Open AccessPROLIFERATIVE RESPONSE IN THE RAT KIDNEY INDUCED BY A SINGLE, CARCINOGENIC DOSE OF DIMETHYLNITROSAMINE
Author(s) -
Hard G. C.,
Shaw D. M.
Publication year - 1974
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1974.tb00427.x
Subject(s) - carcinogen , kidney , dna synthesis , medulla , cortex (anatomy) , dna , chemistry , kidney cortex , biology , mesenchymal stem cell , medicine , endocrinology , pathology , anatomy , physiology , microbiology and biotechnology , neuroscience , biochemistry
With the application of autoradiography, the pattern of DNA synthetic activity in the rat kidney following a carcinogenic dose of DMN was traced during the 3 weeks following treatment. Depending on cell class and location, DNA synthesis was constantly depressed for the first 1 or 2 days throughout all zones of the kidney. Mesenchymal cells of the cortex and outer band of the outer medulla commenced a wave of stimulated activity at the third day with a peak of response at the sixth day. Epithelial cells of these same two zones were slower to respond, attaining a peak of DNA synthetic activity at the tenth day. By the start of the third week, activity had returned to normal or near‐normal levels. The observations are discussed in relation to the known morphological events which occur in the kidneys of DMN‐treated rats prior to the development of neoplasia.