Open AccessCELL POPULATION KINETICS OF TRANSPLANTED AND METASTATIC LEWIS LUNG CARCINOMA
Author(s) -
SimpsonHerren L.,
Sanford A. H.,
Holmquist J. P.
Publication year - 1974
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1974.tb00417.x
Subject(s) - doubling time , lewis lung carcinoma , lung , primary tumor , carcinoma , pathology , medicine , population , concomitant , mitotic index , cell , metastasis , biology , mitosis , cancer , genetics , environmental health , microbiology and biotechnology
The growth rate of Lewis lung carcinoma, either as primary subcutaneous tumors or as spontaneous lung metastases, decreases with increasing age or mass. The length of the median cell cycle of the primary tumors increased from 17.6 hr at Day 5 to 25.9 hr at Day 21 with a concomitant increase in experimental doubling time from 2.5 to 9.6 days. The length of the median cell cycle of the metastatic lung nodules was 15.2 hr in the mice bearing 21‐day primary tumors. Two mathematical models were used to analyse the per cent labeled mitoses data and the results are given for comparison. The labeling index of the primary tumors decreased in a nearly linear manner with time postimplant and the percentage of cells labeled in the metastatic nodules was higher than in the primary tumors when measured in the same hosts.