Open AccessCORRELATION BETWEEN TISSULAR AND DIVISION FUNCTIONS IN THE LIVER OF YOUNG RATS
Author(s) -
Barbason H.,
Cantfort J. Van,
Houbrechts N.
Publication year - 1974
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1974.tb00414.x
Subject(s) - evening , circadian rhythm , period (music) , mitosis , endocrinology , biology , medicine , cell division , rhythm , microbiology and biotechnology , biochemistry , cell , physics , astronomy , acoustics
The division and tissue specific functions are studied in the liver of young rats during the first post‐natal weeks. The division function is tested by the mitotic and the 3 H‐thymidine labelling index, the specific tissular function by the cholesterol‐7 alpha‐hydroxylase activity. The nycthemeral rhythm is triggered simultaneously for the two functions at the 20th day of life. From this time, spontaneous or induced mitoses occur during the day (rest period) and the cholesterol‐7‐alpha‐hydroxylase during the evening (period of activity). The results are explained by the influence of the hypothalamoadrenal axis, which presents a circadian activity with a maximum in the evening.