Open AccessTHE INFLUENCE OF ADRENORECEPTOR ACTIVITY ON CRYPT CELL PROLIFERATION IN THE RAT JEJUNUM
Author(s) -
Tutton P. J. M.,
Helme R. D.
Publication year - 1974
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1974.tb00405.x
Subject(s) - phentolamine , practolol , stimulation , adrenergic , propranolol , mitosis , medicine , endocrinology , cell cycle , blockade , chemistry , biology , cell , microbiology and biotechnology , biochemistry , receptor
The influence of adrenergic stimulation, adrenergic blockade and sympathectomy on crypt cell cycle time and mitotic time in rat jejunum was studied. Alpha adrenergic stimulation by noradrenaline was found to shorten both cell cycle and mitotic times, whereas beta adrenergic stimulation by adrenaline or isoprenaline was found to prolong both cell cycle and mitotic times. Conversely, alpha adrenergic blockade by phentolamine prolonged cell cycle time and beta adrenergic blockade by propranolol or practolol shortened cell cycle time but not mitotic time. Both chemical and surgical sympathectomy inhibited crypt cell proliferation. Chemically sympathectomized animals manifested supersensitivity to exogenous noradrenaline.