Open AccessPROLIFERATION OF LIVER EPITHELIA IN THREE‐WEEK‐OLD RATS
Author(s) -
Schultze B.,
Maurer W.
Publication year - 1973
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1973.tb01635.x
Subject(s) - thymidine , mitosis , parenchyma , fraction (chemistry) , cell cycle , growth curve (statistics) , endocrinology , biology , medicine , andrology , chemistry , biochemistry , microbiology and biotechnology , in vitro , cell , chromatography , mathematics , econometrics , botany
The proliferative activity of liver epithelia in 3‐week‐old rats was studied auto‐radiographically using 3 H‐thymidine. Only a single peak of labelled mitoses (late pro‐ to anaphases) at 7 hr was found in the per cent labelled mitoses curve after injection of 3 H‐thymidine. A second peak at about 32 hr described by Post, Huang & Hoffman (1963) and Post & Hoffman (1964, 1965) as well as Grisham (1969) and a cycle time of about 22 hr derived from the distance between the two peaks could not be confirmed by the present work. According to the present experiments the cycle time of parenchymal liver cells in 3‐week‐old rats must range between 50 hr (with a growth fraction of 0·25) and 7·1 days (with a growth fraction of 1·0). The present results do not support the existence of a growth fraction of only 0·1 as assumed by Post et al. (1963).