Open AccessTHE ALTERATION OF THE REGENERATIVE ACTIVITY AND THE CELL CYCLE OF PARTIALLY HEPATECTOMIZED RAT LIVER FOLLOWING ADMINISTRATION OF d ‐GALACTOSAMINE
Author(s) -
Lesch R.,
Bachmann W.,
Reutter W.
Publication year - 1973
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1973.tb01620.x
Subject(s) - galactosamine , thymidine , dna synthesis , liver regeneration , cell cycle , dna , regeneration (biology) , chemistry , cell , biochemistry , biology , microbiology and biotechnology , medicine , glucosamine
A single injection of d‐galactosamine given to rats at different times after partial hepatectomy (PH) changes the pattern of regenerative proliferation. When administered during the pre‐replicative phase of regeneration, the onset of DNA synthesis and the increase in labelling index after injection of 3 H‐thymidine are delayed by about 12 hr. The injection of d‐galactosamine at 24 hr after PH inhibits the drop in DNA synthesis occurring normally during the following 12 hr period. This was detected by a high labelling index and by an increased specific activity of DNA. The findings indicate a lengthening of the S phase, while G 2 and M remain normal. Two modes of action of d‐galactosamine on the cell cycle are discussed.