Open AccessAN ESTIMATION OF PROLIFERATIVE POPULATION SIZE IN STOMACH, JEJUNUM AND COLON OF DBA‐2 MICE
Author(s) -
Kovacs Laszlo,
Potten Christopher S.
Publication year - 1973
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1973.tb01601.x
Subject(s) - jejunum , stomach , crypt , gastrointestinal tract , population , biology , ileum , medicine , gastroenterology , environmental health
Liquid scintillation and autoradiographic techniques have been used to provide quantitative data on the proliferative units, the crypts, of stomach, jejunum and colon of DBA‐2 mice. A slight modification of the crypt squash technique has provided data suggesting that about 50% of the cells of the jejunal crypt are at any given time in the proliferative state. This value is lower in the colon while in the stomach glands only 20% of the cells are involved in cell production. The data provide estimates for cell cycle times of 26·3, 16·0 and 23·2 hr for stomach, jejunum and colon respectively. The size and number of proliferative units have been determined for three regions of the gastrointestinal tract of mice. A review of the literature suggests that considerable strain differences may exist.