Open AccessTHE EFFECT OF METHYL CCNU (NSC‐95441) ON THE CELLULAR KINETICS OF NORMAL AND LEUKEMIC MURINE TISSUES IN VIVO
Author(s) -
Young Robert C.
Publication year - 1973
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1973.tb01592.x
Subject(s) - in vivo , chemistry , thymidine , gastrointestinal tract , bone marrow , leukemia , kinetics , in vitro , pharmacology , cancer research , immunology , biology , biochemistry , physics , microbiology and biotechnology , quantum mechanics
The effect of MeCCNU on the cellular kinetics of normal and leukemic murine tissues is examined in vivo . A prolongation in the S phase is noted after doses of MeCCNU as low as 4 mg/kg, and this prolongation persists for approximately 4 hr after the dose. No persistent alteration in the growth fraction is produced by MeCCNU. The generation time of the cells regrowing after MeCCNU is slightly prolonged, compared to normal L1210 leukemia. Simultaneous studies on ascites tumor, normal bone marrow, and normal gastrointestinal mucosa, using the in vivo uptake of 3 H‐thymidine into DNA, have shown a differential effect on the tumor and normal tissues.