Open AccessCOLONY FORMING CELLS IN THE LIVERS OF PRENATAL FLEXED ( f/f ) ANAEMIC MICE
Author(s) -
Bateman A. E.,
Cole R. J.
Publication year - 1972
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1972.tb01013.x
Subject(s) - erythropoiesis , spleen , biology , andrology , fetus , stem cell , colony forming unit , embryo , genotype , transplantation , gestation , microbiology and biotechnology , immunology , medicine , genetics , pregnancy , gene , anemia , bacteria
The colony forming unit (c.f.u.) content of foetal livers of f/f and f /+ genotypes has been investigated. Although proportions of c.f.u. to nucleated liver cells do not vary with genotype, the total number of c.f.u. and erythroid cells per foetus is reduced in f/f embryos from 11 to 16 days of gestation. The differentiative capacity of f/f stem cells, measured by 59 Fe uptake into blood 7 days after transplantation of cells, was less than that of f /+ stem cells. An initially low growth rate of c.f.u. in early foetal liver and in young spleen colonies can explain several characteristics of flexed erythropoiesis.