Open AccessCELL PROLIFERATION IN HAEMATOPOIETIC SPLEEN COLONIES OF MICE: DIFFERENCE BETWEEN COLONIES DERIVED FROM INJECTED ADULT BONE MARROW AND FOETAL LIVER CELLS
Author(s) -
Micklem H. S.
Publication year - 1972
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1972.tb01012.x
Subject(s) - haematopoiesis , spleen , bone marrow , stem cell , biology , immunology , cell , pathology , microbiology and biotechnology , medicine , genetics
Cell proliferation in mouse spleen colonies, derived from injected foetal liver and young adult bone marrow, was studied by measuring incorporation of radio‐iodine‐labelled 5‐iodo‐2′‐deoxyuridine (IUdR). Foetal liver‐derived colonies incorporated significantly more IUdR than marrow‐derived colonies on the 8th and 12th days after cell injection. The data are consistent with the view that foetal haematopoietic stem cells are capable, on average, of producing larger descendant populations than are stem cells from young adults.