Open AccessCELL KINETICS OF GROWTH CARTILAGE IN THE RAT TIBIA II. MEASUREMENTS DURING AGEING
Author(s) -
Walker K. V. R.,
Kember N. F.
Publication year - 1972
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1972.tb00379.x
Subject(s) - ageing , cartilage , tibia , cell growth , kinetics , bone growth , doubling time , chemistry , andrology , cell , anatomy , biology , endocrinology , microbiology and biotechnology , biophysics , medicine , biochemistry , physics , quantum mechanics
A number of cell kinetic techniques using labelled thymidine and autoradiography have been applied to study growth cartilage in the rat tibia during ageing. No change in the duration of the synthesis phase was found from 4 to 13 weeks of age but there was a reduction in cell proliferation rate during this period. Measurements of labelling index, proliferation zone size and height of hypertrophic cells were used to calculate the growth rate of the bone from 7 days to 1 year. The results agreed well with radiographic measurements of bone growth.