Open AccessTHE DISTRIBUTION OF MONOCYTES IN THE RAT
Author(s) -
Whitelaw D. M.,
Batho H. F.
Publication year - 1972
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1972.tb00360.x
Subject(s) - spleen , compartment (ship) , monocyte , iron isotopes , distribution (mathematics) , blood circulation , splenectomy , circulation (fluid dynamics) , immunology , chemistry , biology , medicine , mechanics , geology , physics , isotope , mathematical analysis , oceanography , mathematics , quantum mechanics , traditional medicine
In the rat, labeled transfused monocytes initially leave the circulation with a halftime of 0.2 hr. They first collect on the walls of small vessels then migrate outward until equilibrium is established between the circulating pool and a large extravascular pool which contains about twenty‐five times as many monocytes as the circulating blood. From this pool they leave randomly and irreversibly with a halftime of 14 hr. The spleen and lungs make up a large part of the pool and splenectomy reduces the size of the extravascular compartment and slows the rate of sequestration.