Open AccessDNA‐SYNTHESIS TIME OF BONE MARROW CELLS IN HEALTHY AND ASCITES TUMOR‐BEARING MICE
Author(s) -
Lala P. K.
Publication year - 1972
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1972.tb00357.x
Subject(s) - dna synthesis , bone marrow , in vitro , ascites , in vivo , ehrlich ascites , dna , tumor cells , biology , neoplasm , cancer research , microbiology and biotechnology , immunology , pathology , medicine , biochemistry , genetics
DNA‐synthesis (S) times of myelocytes and nucleated erythroid cells in the bone marrow of healthy mice as well as mice bearing advanced Ehrlich ascites tumors were measured with the aid of a combined in vivo‐in vitro double isotope labeling technique. Neither the S‐period nor the rate of proliferation of these cells were influenced by the presence of the tumor in these hosts. This finding discounts the possibility that the marked retardation of DNA‐synthesis and proliferation rate observed in the tumor cells themselves with advancing tumor‐age is a nonspecific effect of the nutritional deterioration in the host.