Open AccessMECHANISM OF EOSINOPHILIA
Author(s) -
Spry Christopher J. F.
Publication year - 1971
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1971.tb01546.x
Subject(s) - eosinophil , eosinophilia , trichinella spiralis , immunology , trichinosis , spleen , biology , medicine , helminths , asthma
The kinetics of non‐dividing eosinophils was studied in normal rats and rats in which an eosinophilia had been induced by injecting Trichinella spiralis larvae intravenously. the findings suggested that in normal rats eosinophils matured in the spleen after leaving the marrow. the emergence time of eosinophils in normal rats was 41 hr, and was reduced in stimulated rats to 18 hr. Neutrophil emergence time was not reduced, indicating that there are separate mechanisms for regulating the rates of emergence of newly formed eosinophils and neutrophils. The half‐life of eosinophils in the blood of normal rats was 6.7 hr, and was not altered 1.5–3.5 days after larvae were injected, when many eosinophils were accumulating in tissues. the rate of disappearance of labelled eosinophils from the blood was exponential, indicating random loss from the circulation. Eosinophils were mobilized into the pool of circulating eosinophils by a soluble plasma factor (‘eosinophil releasing factor’) which increased the number of circulating eosinophils at 3 and 6 hr. These experiments showed that the number of eosinophils in the blood was regulated by several different mechanisms, which were distinct from those affecting eosinophil production.