Open AccessEXCLUSION OF SERUM FACTORS IN THE IN‐VITRO DEPRESSION OF LYMPHOCYTES’ RESPONSE TO MITOGENS IN CHRONIC LYMPHOCYTIC LEUKAEMIA
Author(s) -
Pentycross Christopher R.
Publication year - 1971
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1971.tb01542.x
Subject(s) - in vitro , immunology , depression (economics) , chronic lymphocytic leukemia , inhibitory postsynaptic potential , biology , medicine , leukemia , biochemistry , economics , macroeconomics
To find out whether serum factors are involved in the depression of the mitogenic response of lymphocytes of patients with chronic lymphocytic leukaemia, sera from these patients were used in the culture medium for normal lymphocytes. the results were considered on the basis of the dynamics of responses of these normal lymphocytes, comparing a standard human group AB serum with twenty sera from patients with CLL. No heat‐stable inhibitory factors peculiar to CLL were found. In an experiment in which fresh CLL and normal sera were compared, no heat‐labile inhibitory factors were apparent.