Open AccessGROWTH HORMONE AND CARTILAGE CELL DIVISION IN HYPOPHYSECTOMIZED RATS
Author(s) -
Kember N. F.
Publication year - 1971
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1971.tb01529.x
Subject(s) - hypophysectomy , labelling , endocrinology , medicine , growth hormone , cell division , hormone , thymidine , cell , cartilage , bovine somatotropin , biology , cell growth , chemistry , anatomy , in vitro , biochemistry
The effects of growth hormone on cell division in the growth cartilage of normal and hypophysectomized rats have been studied by autoradiography with tritiated thymidine. Following hypophysectomy the percentage labelling fell to 1.5‐2%, about one fifth of that found in normal animals. Following injection of 100‐1600 μg of bovine growth hormone, the percentage labelling increased after a delay of 8‐16 hr, the delay, the rate of rise and the maximum reached being dose dependent. Single or repeated doses of growth hormone produced no significant change in normal young rats.