Open AccessA STUDY ON INEFFECTIVE ERYTHROPOIESIS IN THE DOG
Author(s) -
Odartchenko Nicolas,
Cottier Hans,
Bond Victor P.
Publication year - 1971
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1971.tb01521.x
Subject(s) - erythropoiesis , bone marrow , biology , cell , dna synthesis , normal group , andrology , dna , microbiology and biotechnology , immunology , medicine , endocrinology , genetics , anemia
Erythrocytic cell kinetics were studied in normal dog bone marrow, at the transition between younger cells that are able to synthesize DNA, and more mature nucleated normoblasts which have lost this ability. the rate of progression out of the first group was compared to that into the second, after necessary adjustments of group sizes. No significant discrepancy was detected within the limits of resolution of autoradiographic cytokinetic analysis. It is concluded that ‘ineffective’ red cell production in the normal dog, if it occurs at all, can only be very small in quantity.