Open AccessKINETICS OF A DRUG SENSITIVE CLONE OF HeLa CELLS
Author(s) -
Nias A. H. W.,
Fox Margaret,
Fox B. W.
Publication year - 1970
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1970.tb00266.x
Subject(s) - hela , clone (java method) , kinetics , population , drug , microbiology and biotechnology , biology , chemistry , cell , biochemistry , gene , pharmacology , medicine , physics , environmental health , quantum mechanics
Drug sensitive clones have been isolated from a population of HeLa cells after treatment with methyl methane sulphonate (MMS). One of these clones has now been studied in more detail and some possible mechanisms of drug sensitivity have been related to the proliferation kinetics of the cells of this clone. The cell cycle is elongated and labelling techniques show this elongation to be confined to the G 1 phase. Synchronized cultures have shown that the G 1 phase is more sensitive to MMS than the S phase. These observations provide some explanation for the drug sensitivity of this clone of cells.