Open AccessERYTHROPOIETIN SENSITIVITY OF RAT BONE MARROW CELLS SEPARATED BY VELOCITY SEDIMENTATION
Author(s) -
McCool Dorothy,
Miller R. J.,
Painter R. H.,
Bruce W. R.
Publication year - 1970
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1970.tb00252.x
Subject(s) - sedimentation , bone marrow , erythropoietin , sedimentation coefficient , hemoglobin , in vitro , population , chemistry , biophysics , biology , endocrinology , immunology , medicine , biochemistry , environmental health , sediment , enzyme , paleontology
Rat bone marrow cells have been separated on the basis of their sedimentation at unit gravity. The cell population most responsive to erythropoietin in vitro was found to have a sedimentation velocity of about 6.6 mm/hr. In the process of becoming hemoglobin‐synthesizing cells, it undergoes cell division and its sedimentation velocity decreases to 3.9 mm/hr and then to 2.1 mm/hr, the sedimentation velocity of mature red blood cells.